Search on: DNA TOPOISOMERASE II 
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Descriptor English:   DNA Topoisomerases, Type II 
Descriptor Spanish:   Topoisomerasas de ADN Tipo II 
Descriptor Portuguese:   DNA Topoisomerases Tipo II 
Synonyms English:   DNA Type 2 Topoisomerase
Topoisomerase II
Type II DNA Topoisomerase
DNA Topoisomerase (ATP-Hydrolysing)
DNA Topoisomerase II  
Tree Number:   D08.811.399.403.741
Definition English:   DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex. 
Indexing Annotation English:   coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
Entry Combination - descr/qualif English:   DNA Topoisomerases, Type II/antagonists & inhibitors use Topoisomerase II Inhibitors
 
History Note English:   2002; use DNA GYRASE 1980-1993 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   31731 
Unique Identifier:   D004250 

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